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Tacrolimus monohydrate antibyotik imunosupresan

Tacrolimus monohydrate antibyotik imunosupresan

Non angle: Tacrolimus monohydrate
Nimewo CAS: 109581-93-3
Alias ​​angle:
FK-506;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,monohydrate,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;TACROLIMUSHYDRATE/TSUKUBAENOLIDEHYDRATE;(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroChemicalbookxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone;Tacrolimus(150mg);(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-Methoxycyclohexyl]-1-Methylethenyl]-14,16-diMethoxy-4,10,12,18-tetraMethyl-8-(2-propen-1-yl)-;Tacrolimusmonohydrate;FK-506monohydrate,>=98%
Voye rechèch

Pwodwi Deskripsyon

 

Non angle: Tacrolimus monohydrate
Nimewo CAS: 109581-93-3
Fòmil molekilè: C44H71NO13
Pwa molekilè: 822.05
Einecs Non: 617-559-7
Kategori ki gen rapò:
Enpurte tacrolimus; Materyèl medikal anvan tout koreksyon; fèmantasyon; materyèl pharmaceutique anvan tout koreksyon; Koneksyon chimik; sibstans dwòg; antibyotik; Materyèl medikal anvan tout koreksyon; reyaktif chimik; Materyèl chimik anvan tout koreksyon; materyèl anvan tout koreksyon; Siyal; Fine chimik materyèl anvan tout koreksyon.
Dosye a mol: 109581-93-3.

 

Fòmil estriktirèl:

1

 

Ttacrolimus monohydrate pwopriyete
Pwen k ap fonn: 127-129
Wotasyon espesifik: D 23-84. 4 (C=1. 02 nan kloroform)
Kondisyon depo: -20 C
Solubility: DMSO: soluble, 20 mg/ml
Fòm: poud
Koulè: blan prèske blan
Merck: 14,9025
Inchikey: nwjqlqgqzsibaf-mlauyuebsa-n
 

Sèvi ak metòd sentetik nan Tacrotamus US monohydrate

 

 Byoaktivite

Tacrolimus monohydrate (FK506 Monohydrate) se yon konpoze makrolid. Tacrolimus monohydrate mare nan pwoteyin nan obligatwa FK506 (FKBP) yo fòme yon konplèks ak inibit calcineurin (calcineurin fosfataz), kidonk anpeche T siyal lenfosit ak IL -2 transkripsyon. Ak pwopriyete imunosupresif fò.

 

 Plas sib

Pp2b (calcineurin fosfataz)

Autophagy Inducer

 

 Etid in vitro

Tacrolimus monohydrate (FK506 monohydrate; fujimycin monohydrate; FR900506 monohydrate inibit evènman selil depandan tankou IL {{2} Progesterone sou FKBP ki genyen nan konplèks reseptè òmòn, anpeche degradasyon li yo. Efè sou proliferasyon nan MH3924a selil (P =0. 135).<0.01). Treatment with AMD3100 concentrations (10, 50, or 100 μ g/L) had no significant effect on the proliferation of MH3924 cells (P>0. 05). Sepandan, lè konsantrasyon diferan nan AMD3100 yo te konbine avèk 100 μ g/L acrolimus, pwopagasyon an vitro nan MH3924ACell ogmante (P<0.01).

 

 Nan Vivo Rechèch

Efè ki ka geri ou nan tacrolimus te etidye pou pwogresyon an ak pèrsistans nan kolit pa konbine tacrolimus ak sodyòm dextran (DSS) tretman nan sourit soti nan jou 10 a jou 16 oswa jou 23. Nan 17yèm jou yo ak 24th, longè nan kolon an siyifikativman pi kout ak pwa nan kolon an siyifikativman. Bèt kontwòl yo trete ak DSS yo te konpare ak bèt nòmal. Anplis de sa, pwa kolon an pou chak longè inite nan gwoup kontwòl la te plis pase de fwa sa yo ki an gwoup la kontwòl chimik. Malgre ke tretman ak tacrolimus pou 7 ak 14 jou siyifikativman inibe ogmantasyon nan pwa kolon pou chak longè inite nan DSS bèt trete konpare ak gwoup la kontwòl, tretman sa a pa t 'vrèman retabli manton kolon. Anplis de sa, efè a inhibition nan tacrolimus sou ogmantasyon nan pwa kolon pou chak longè inite te pi pwononse nan 14 jou a ak 7- tretman jou, jan yo montre nan pousantaj la anpèchman (59% vs 28%).

 

 Enfòmasyon Sekirite Sosyal

Mak danjere: T

Kòd Kategori Danje: 25

Enstriksyon Sekirite: 45

Nimewo transpò danjere pou machandiz: un 2811 6. 1 / pg 3

WGK Almay: 3

RTECS Non: KD4201200

Nivo danje: 6.1

Kategori anbalaj: III

Kòd Ladwàn: 2934990002

toxicity:LD50i.p.inmice:>2 0 0mg/kg (kino); lchemicalbookd50inmale, femalerats (mg/kg): 57.0,23.6iv; 134,194orally (ohara)

 

Baj popilè: Tacrolimus monohydrate antibyotik imunosupresan, Lachin Tacrolimus monohydrate antibyotik imunosupresan founisè